Paul's instruction "without anger or disputing" was probably because Timothy's group had been doing just that. It reminds me of Jesus' admonition in Matthew 5:23-24, "If you are offering your gift at the altar and there remember that your brother has something against you, leave your gift there in front of the altar. First go and be reconciled to your brother; then come and offer your gift". Lifting hands and hearts is difficult when we are angry or arguing with someone.
For reflection: What posture(s) do I assume when in prayer? Do they differ with the type of prayer (prayer of thanksgiving, praise, petition, sorrow)?
Let us pray. Today, Father, I lift up my holy hands in praise to you. You are the King, eternal, immortal, invisible. You are my source of inspiration. Honor and glory are yours forever and ever.